Everything about Etoposide totally explained
Etoposide phosphate (brand names:
Eposin,
Etopophos,
Vepesid,
VP-16) is an inhibitor of the
enzyme topoisomerase II. It is used as a form of
chemotherapy for malignancies such as Ewing's sarcoma,
lung cancer,
testicular cancer,
lymphoma, non-lymphocytic
leukemia, and
glioblastoma multiforme. It is often given in combination with other drugs.
Chemically it derives from
podophyllotoxin, a toxin found in the
American Mayapple.
Administration
It is given intravenously or orally in capsule form. If the drug is given by IV it must be done slowly over a 30 to 60 minute period because it can lower
blood pressure as it's being administered. Blood pressure is checked often during infusing with the speed of administration adjusted accordingly.
Patients are generally advised to call their doctor in case of
fever, symptoms of
infection or painful injection sites, as these may progress severely without adequate medical attention.
Patients are advised to drink large amounts of fluids after treatment to prevent damage to the
bladder and
kidneys, typically 1.5 to 3.5 litres of
water on the day of treatment and for several days after.
Side effects
Common are:
Less common are:
nausea and vomiting
allergic type reactions
rash
fever, often occurring shortly after IV administration and not due to infection
mouth sores
Acute myeloid leukemia
External links
Further Information
Get more info on 'Etoposide'.
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